Research

DAIRY CATTLE GENOMICS

Genomic analysis of relevant traits that affect animal productivity and welfare in dairy cattle, with special emphasis on fertility and health traits.

Some recent publications:

LC Novo, L Cavani, P Pinedo, P Melendez, and F Peñagaricano (2022)
Genomic analysis of visceral fat accumulation in Holstein cows.
Frontiers in Genetics 12: 803216.

L Cavani, MB Poindexter, CD Nelson, JEP Santos, and F Peñagaricano (2022)
Gene mapping, gene-set analysis, and genomic prediction of postpartum blood calcium in Holstein cows.
Journal of Dairy Science 105: 525-534.

HA Pacheco, M Battagin, A Rossoni, A Cecchinato, and F Peñagaricano (2021)
Evaluation of bull fertility in Italian Brown Swiss dairy cattle using cow field data.
Journal of Dairy Science 104: 10896-10904.

NUTRITIONAL & ENVIRONMENTAL GENOMICS

Evaluation of the effects of prenatal factors on the epigenome and transcriptome of the offspring.

Some recent publications:

L Liu, R Amorín, P Moriel, N DiLorenzo, PA Lancaster, and F Peñagaricano (2021)
Maternal methionine supplementation during gestation alters alternative splicing and DNA methylation in bovine skeletal muscle.
BMC Genomics 22: 780.

EA Palmer, F Peñagaricano, M Vedovatto, RA Oliveira, SL Field, J Laporta, and P Moriel (2021)
Effects of maternal gestational diet on muscle transcriptome of beef calves following a vaccine-induced immunological challenge.
PLoS ONE 16: e0253810.

L Liu, R Amorín, P Moriel, N DiLorenzo, PA Lancaster, and F Peñagaricano (2020)
Differential network analysis of bovine muscle reveals changes in gene coexpression patterns in response to changes in maternal nutrition.
BMC Genomics 21: 684.

NETWORK MODELING

Inference of gene-phenotype networks in multivariate genetic systems.

Some recent publications:

H Louvandini, PS Corrêa, R Amorín, L Liu, EH Ieda, CR Jimenez, SM Tsai, CM McManus, and F Peñagaricano (2020)
Gestational and lactational exposure to gossypol alters the testis transcriptome.
BMC Genomics 21: 59.

JD Leal Gutierrez, FM Rezende, MA Elzo, DD Johnson, F Peñagaricano, and RG Mateescu (2018)
Structural equation modeling and whole-genome scans uncover chromosome regions and enriched pathways for carcass and meat quality in beef.
Frontiers in Genetics 9: 532.

COMPUTATIONAL BIOLOGY AND BIOINFORMATICS

Analysis of transcriptional and DNA methylation profiling experiments using sequence data

Some recent publications:

E Jara, F Peñagaricano, E Armstrong, C Menezes, L Tardiz, G Rodons, and A Iriarte (2022)
Identification of long noncoding RNAs involved in eyelid pigmentation of Hereford cattle.
Frontiers in Genetics 13: 864567.

CM Sheftel, L Liu, SL Field, SR Weaver, CM Vezina, F Peñagaricano, and LL Hernandez (2022)
Impact of fluoxetine treatment and folic acid supplementation on the mammary gland transcriptome during peak lactation.
Frontiers in Pharmacology 13: 828735.

T Martins, M Sponchiado, FACC Silva, E Estrada-Cortés, PJ Hansen, F Peñagaricano, and M Binelli (2022)
Progesterone-dependent and -independent modulation of luminal epithelial transcription to support pregnancy in cattle.
Physiological Genomics 54: 71–85.